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Test Code FIBAG Fibrinogen Antigen, Plasma

Useful For

Evaluation of fibrinogen deficiency

 

Measuring fibrinogen in patients with elevated plasma levels of fibrin degradation products, patients receiving heparin, and in patients with antibodies to thrombin (following surgical use of topical bovine thrombin)

 

Identifying afibrinogenemia, hypofibrinogenemia, and dysfibrinogenemia when ordered in combination with fibrinogen activity (FIBTP / Fibrinogen, Plasma)

Method Name

Immunoturbidimetric

Reporting Name

Fibrinogen Antigen, P

Specimen Type

Plasma Na Cit


Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube: Light-blue top (3.2% sodium citrate at 9:1 ratio)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot plasma into plastic vial. Send refrigerated.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Refrigerated (preferred) 14 days
  Frozen  30 days
  Ambient  72 hours

Reference Values

≥18 years: 196-441 mg/dL

Reference values have not been established for patients that are less than 18 years of age.

Interpretation

This method measures the total amount of fibrinogen protein (ie, fibrinogen antigen) present in the plasma.

 

Adequate fibrinogen antigen levels in a context of low fibrinogen activity suggests a dysfibrinogenemia.

 

Fibrinogen antigen levels lower than 100 mg/dL are associated with an increased risk of bleeding.

Clinical Reference

1. de Moerloose P, Casini A, Neerman-Arbez M. Congenital fibrinogen disorders: an update. Semin Thromb Hemost. 2013;39(6):585-595

2. Mackie I, Casini A, Pieters M, Purthi R, Reilly-Stitt C, Suzuki A. International council for standardisation in haematology recommendations on fibrinogen assays, thrombin clotting time and related tests in the investigation of bleeding disorders. Int J Lab Hematol. 2024;46(1): 20-32. doi:10.1111/ijlh.14201

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

85385

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FIBAG Fibrinogen Antigen, P 3256-5

 

Result ID Test Result Name Result LOINC Value
FIBAG Fibrinogen Antigen, P 3256-5