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Test Code EAEBV Epstein-Barr Virus Early Antigen, IgG, Serum


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Diagnosis of Epstein Barr virus (EBV) infectious mononucleosis in cases when heterophile antibody test results are negative and EBV-specific serologic testing is inconclusive

 

Aiding in the diagnosis of type 2 or type 3 nasopharyngeal carcinoma (NPC)

 

This test is not useful for screening patients for NPC.

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

EBV EA IgG, S

Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 14 days
  Refrigerated  48 hours

Reference Values

Negative

Reference values apply to all ages.

Interpretation

Positive - IgG antibodies specific to EBV early antigen detected.

Equivocal - Recommend follow-up testing in 10-14 days if clinically indicated

Negative - No IgG to EBV early antigen detected.

 

Do not make a diagnosis based on ZEUS ELISA EBV-EA IgG Test System alone. Interpret test results for anti-EBV-early antigen (EA) in conjunction with the clinical evaluation and the results of other diagnostic procedures. Consider test results for VCA and EBNA when evaluating patient specimens for EBV serological status.

Clinical Reference

1. Fields BN, Knipe DM. Epstein-Barr virus. In: Fields BN, Knipe DM, Howley PM, eds. Fields Virology. 4th ed. Lippincott Williams and Wilkins; 2001

2. Lennette ET. Epstein-Barr virus. In: Murray PR, Baron EJ, Pfaller MA, et al, eds. Manual of Clinical Microbiology. 6th ed. ASM Press; 1995:905-910

3. Fugl A, Andersen CL. Epstein-Barr virus and its association with disease - a review of relevance to general practice. BMC Fam Pract. 2019;20(1):62. doi:10.1186/s12875-019-0954-3

Day(s) Performed

Tuesday; Thursday

Report Available

Same day/1 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86663

LOINC Code Information

Test ID Test Order Name Order LOINC Value
EAEBV EBV EA IgG, S 40752-8

 

Result ID Test Result Name Result LOINC Value
EBVEA EBVEA IgG, S 40752-8