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Test Code DOGPF Dog Dander, IgE, with Reflex to Dog Dander Components, IgE, Serum


Ordering Guidance


For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Evaluating patients with suspected dog dander allergy

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
DOGPR Dog Dander Components, IgE, S No No

Testing Algorithm

Testing begins with analysis of dog dander IgE. If dog dander IgE is negative (<0.10 kU/L), testing is complete.

 

If dog dander IgE is 0.10 kU/L or more, then 6 dog dander components (Can f 1, Can f 2, Can f 3, Can f 4, Can f 5, Can f 6) are performed at an additional charge.

Method Name

Fluorescent Enzyme Immunoassay (FEIA)

Reporting Name

Dog Dander Component Reflex, S

Specimen Type

Serum

Specimen Minimum Volume

0.7 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  90 days

Reference Values

Class

IgE kU/L

Interpretation

0

<0.10

Negative

0/1

0.10-0.34

Borderline/equivocal

1

0.35-0.69

Equivocal

2

0.70-3.49

Positive

3

3.50-17.4

Positive

4

17.5-49.9

Strongly positive

5

50.0-99.9

Strongly positive

6

≥100

Strongly positive

Concentrations of 0.70 kU/L or more (class 2 and above) will flag as abnormally high.

Reference values apply to all ages.

Interpretation

When detectable total dog dander IgE antibody is present (≥0.10 IgE kUa/L), additional specific component IgE antibody testing will be performed. If at least one potential specific allergenic dog dander component IgE is detectable (≥0.10 IgE kUa/L), an interpretative report will be provided.

 

When the sample is negative for total dog dander IgE antibody (<0.10 IgE kUa/L), additional testing for specific dog component IgE antibodies will not be performed. Negative IgE results for total dog dander antibody may indicate a lack of sensitization to potential dog allergenic components.

Clinical Reference

1. Mattsson L, Lundgren T, Everberg H, et al: Prostatic kallikrein: a new major dog allergen. J Allergy Clin Immunol. 2009 Feb;123(2):362-368

2. Davila I, Dominguez-Ortega J, Navarro-Pulido A, et al: Consensus document on dog and cat allergy. Allergy. 2018 Jun;73(6):1206-1222. doi: 10.1111/all.13391

3. Nilsson OB, Binnmyr J, Zoltowska A, Saarne T, van Hage M, Gronlund H: Characterization of the dog lipocalin allergen Can f 6: the role in cross-reactivity with cat and horse. Allergy. 2012;67(6):751-757

4. Konieczny A, Morgenstern JP, Bizinkauskas CB, et al: The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms. Immunology. 1997;92(4):577-586

5. Schou C, Svendsen UG, Lowenstein H: Purification and characterization of the major dog allergen, Can f I. Clin Exp Allergy. 1991;21(3):321-328

6. Bjerg A, Winberg A, Berthold M, Mattsson L, Borres MP, Ronmark E: A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren. Pediatr Allergy Immunol. 2015 Sept;26(6):557-563

7. Konradsen JR, Fujisawa T, van Hage M, et al: Allergy to furry animals: New insights, diagnostic approaches, and challenges. J Allergy Clin Immunol. 2015;135(3):616-625

8. Spitzauer S, Pandjaitan B, Soregi G, et al. IgE cross-reactivities against albumins in patients allergic to animals. J Allergy Clin Immunol. 1995;96(6 Pt 1):951-959

9. Chruszcz M, Mikolajczak K, Mank N, Majorek KA, Porebski PJ, Minor W: Serum albumins-unusual allergens. Biochim Biophys Acta. 2013;1830(12):5375-5381

10. Nwaru BI, Suzuki S, Ekerljung L, et al: Furry animal allergen component sensitization and clinical outcomes in adult asthma and rhinitis. J Allergy Clin Immunol Pract. 2019;7(4):1230-1238.e4

11. Schoos AM, Kattan JD, Gimenez G, Sampson HA: Sensitization phenotypes based on protein groups and associations to allergic diseases in children. J Allergy Clin Immunol. 2016 Apr;137(4):1277-1280

12. Rytkonen-Nissinen M, Saarelainen S, Randell J, Hayrinen J, Kalkkinen N, Virtanen T. IgE reactivity of the dog lipocalin allergen Can f 4 and the development of a sandwich ELISA for its quantification. Allergy Asthma Immunol Res. 2015 Jul;7(4):384-392

13. Schoos AM, Bonnelykke K, Chawes BL, Stokholm J, Bisgaard H, Kristensen B: Precision allergy: Separate allergies to male and female dogs. J Allergy Clin Immunol Pract. 2017 Nov-Dec;5(6):1754-1756

14. Basagana M, Bartolome B, Pastor-Vargas C, Mattsson L, Lidholm J, Labrador-Horrillo M: Involvement of Can f 5 in a case of human seminal plasma allergy. Int Arch Allergy Immunol. 2012;159(2):143-146

15. Chan SK, Leung DYM: Dog and cat allergies: Current state of diagnostic approaches and challenges. Allergy Asthma Immunol Res. 2018 Mar;10(2):97-105. doi: 10.4168/aair.2018.10.2.97

16. Salo PM, Arbes SJ Jr, Jaramillo R, et al: Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. J Allergy Clin Immunol. 2014 Aug;134(2):350-359. doi: 10.1016/j.jaci.2013.12.1071

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86003

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DOGPF Dog Dander Component Reflex, S 6098-8

 

Result ID Test Result Name Result LOINC Value
DOGD1 Dog Dander, IgE, S 6098-8

Forms

If not ordering electronically, complete, print, and send an Allergen Test Request (T236) with the specimen.