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HelpTest Code DENGM Dengue Virus Antibody, IgG and IgM, Serum
Useful For
Aiding in the diagnosis of dengue virus infection
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| DENG | Dengue Virus Ab, IgG, S | No | Yes |
| DENM | Dengue Virus Ab, IgM, S | No | Yes |
| DNABI | Dengue Ab Interpretation | No | Yes |
Reporting Name
Dengue Virus Ab, IgG and IgM, SSpecimen Type
SerumSpecimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reference Values
IgG: negative
IgM: negative
Reference values apply to all ages.
Interpretation
The presence of IgG-class antibodies to dengue virus (DV) is consistent with exposure to this virus sometime in the past. By 3 weeks following exposure, nearly all immunocompetent individuals should have developed IgG antibodies to DV.
The presence of IgM-class antibodies to DV is consistent with acute-phase infection.
IgM antibodies become detectable 3 to 7 days following infection and may remain detectable for up to 6 months or longer following disease resolution.
The absence of IgM-class antibodies to DV is consistent with lack of infection. However, specimens collected too soon following exposure may be negative for IgM antibodies to DV. If DV remains suspected, a second specimen collected approximately 10 to 12 days following exposure should be tested.
Clinical Reference
1. Bhatt S, Gething PW, Brady OJ, et al: The global distribution and burden of dengue. Nature. 2013 Apr 25;496(7446):504-507. doi: 10.1038/nature12060
2. Dengue--an infectious disease of staggering proportions. Lancet. 2013 Jun 22;381(9884):2136. doi: 10.1016/S0140-6736(13)61423-3
3. Rigau-Perez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV: Dengue and dengue haemorrhagic fever. Lancet. 1998 Sep 19;352(9132):971-977
4. Tang KF, Ooi EE: Diagnosis of dengue: an update. Expert Rev Anti Infect Ther. 2012 Aug;10(8):895-907. doi: 10.1586/eri.12.76
5. Guzman MG, Kouri G: Dengue diagnosis, advances and challenges. Int J Infect Dis. 2004 Mar;8:69-80
Day(s) Performed
Tuesday
Report Available
Same day/1 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
IgM-86790
IgG-86790
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| DENGM | Dengue Virus Ab, IgG and IgM, S | 87546-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| DENG | Dengue Virus Ab, IgG, S | 29661-6 |
| DENM | Dengue Virus Ab, IgM, S | 29663-2 |
| DNABI | Dengue Ab Interpretation | 69048-7 |
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.