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HelpTest Code CYTH1 T-Helper Cell Type 1 Cytokine Panel, Plasma
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Immediately after specimen collection, place the tube on wet ice.
2. Within 2 hours of collection, centrifuge at 4° C, 1500 x g for 10 minutes and aliquot plasma into a plastic vial
3. Freeze immediately.
Additional Information:
1. Plasma for this test cannot be shared with other tests. Submit specimen for this test in its own vial.
2. This test cannot be added on to a previously collected specimen.
Useful For
Assessment of plasma cytokine levels to understand the etiology of autoimmune and proinflammatory conditions when used in conjunction with clinical information and other laboratory testing
Method Name
Bead-Based Multiplex Immunoassay
Reporting Name
Th1 Cytokine Panel, PSpecimen Type
Plasma EDTASpecimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Frozen | 21 days |
Reference Values
TNF:
<18 years: Not established
≥18 years: <10.0 pg/mL
IFN-gamma:
<18 years: Not established
≥18 years: <60.0 pg/mL
IL-2:
<18 years: Not established
≥18 years: <60.0 pg/mL
IL-2 receptor alpha soluble:
<18 years: Not established
≥18 years: ≤959 pg/mL
IL-12p70:
<18 years: Not established
≥18 years: <200 pg/mL
Interpretation
Elevated cytokine concentrations could be consistent with the presence of infection or other inflammatory process.
Clinical Reference
1. Cerrillo E, Moret I, Iborra M, et al. A nomogram combining fecal calprotectin levels and plasma cytokine profiles for individual prediction of postoperative Crohn's disease recurrence. Inflamm Bowel Dis. 2019;25(10):1681-1691. doi:10.1093/ibd/izz053
2. Li S, Hao X, Gong Y, et al. Effect of shenling baizhu powder on the serum TH1 cytokines of elderly patients with ulcerative colitis complicated by bloody purulent stool. Am J Transl Res. 2021;13(8):9701-9707
3. Abdelrahman AH, Salama, II, Salama SI, et al. Role of some serum biomarkers in the early detection of diabetic cardiomyopathy. Future Sci OA. 2021;7(5):FSO682. doi:10.2144/fsoa-2020-0184
4. Weng L, Chen Y, Liang T, et al. Biomarkers of interstitial lung disease associated with primary Sjogren's syndrome. Eur J Med Res. 2022;27(1):199. doi:10.1186/s40001-022-00828-3
5. Popova V, Geneva-Popova M, Kraev K, Batalov A. Assessment of TNF-alpha expression in unstable atherosclerotic plaques, serum IL-6 and TNF-alpha levels in patients with acute coronary syndrome and rheumatoid arthritis. Rheumatol Int. 2022;42(9):1589-1596. doi:10.1007/s00296-022-05113-4
6. Li L, Chen B, Zhao H, Wang G. Bone changes and curative effect of infliximab in patients with ankylosing spondylitis. J Musculoskelet Neuronal Interact. 2020;20(3):437-443
7. Zhao S, Liu Y, Zhou C, et al. Prediction model of delayed graft function based on clinical characteristics combined with serum IL-2 levels. BMC Nephrol. 2022;23(1):284. doi:10.1186/s12882-022-02908-2
8. Ye Q, Shao WX, Xu XJ, Yang YZ. The clinical application value of cytokines in treating infectious diseases. PLoS One. 2014;9(6):e98745. doi:10.1371/journal.pone.0098745
9. Wang Q, Wang C, Yang M, Li X, Cui J, Wang C. Diagnostic efficacy of serum cytokines and chemokines in patients with candidemia and bacteremia. Cytokine. 2020;130:155081. doi:10.1016/j.cyto.2020.155081
Day(s) Performed
Thursday
Report Available
2 to 8 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83520 x5
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CYTH1 | Th1 Cytokine Panel, P | 82335-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 622037 | TNF | 3074-2 |
| 622038 | IFN-gamma | 27415-9 |
| 622039 | IL-2 | 33939-0 |
| 622040 | IL-2 receptor alpha soluble | 76039-7 |
| 622041 | IL-12p70 | 41760-0 |