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Test Code CRWB Chromium, Blood


Ordering Guidance


High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.



Specimen Required


Container/Tube: Royal blue top (EDTA) Vacutainer plastic trace element blood collection tube

Specimen Volume: 1 mL

Collection Instructions:

1. See Metals Analysis Specimen Collection and Transport for complete instructions.

2. Send whole blood specimen in original tube. Do not aliquot.


Useful For

Monitoring exposure to chromium using whole blood specimens

 

Monitoring metallic prosthetic implant wear

Method Name

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Reporting Name

Chromium, B

Specimen Type

Whole blood

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

0-17 years: Not established

≥18 years: <1.0 ng/mL

Interpretation

Results greater than the reference range indicate exposure to chromium (see Cautions about specimen collection).

 

Prosthesis wear is known to result in increased circulating concentration of metal ions. Increased blood trace element concentrations in the absence of corroborating clinical information do not independently predict prosthesis wear or failure.

Clinical Reference

1. Vincent JB. Elucidating a biological role for chromium at a molecular level. Acc Chem Res. 2000;33(7):503-510

2. Centers for Disease Control and Prevention; National Institute for Occupational Safety and Health (NIOSH): Criteria for a recommended standard occupational exposure to hexavalent chromium. CDC; September 2013. Accessed October 17, 2023. Available at www.cdc.gov/niosh/docs/2013-128/pdfs/2013_128.pdf

3. Keegan GM, Learmonth ID, Case CP. A systematic comparison of the actual, potential, and theoretical health effects of cobalt and chromium exposures from industry and surgical implants. Crit Rev Toxicol. 2008;38:645-674

4. Tower SS. Arthroprosthetic cobaltism: Neurological and cardiac manifestations in two patients with metal-on-metal arthroplasty: A case report. J Bone Joint Surg Am. 2010;92(17):2847-2851

5. US Food and Drug Administration: Information about Soft Tissue Imaging and Metal Ion Testing. FDA; Updated March 15, 2019. Accessed October 17, 2023. Available at: www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/ImplantsandProsthetics/MetalonMetalHipImplants/ucm331971.htm

6. US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry: Toxicology profile for chromium. HHS; September 2012. Accessed March 2, 2021. Available at www.atsdr.cdc.gov/ToxProfiles/tp7.pdf

7. Sodi R. Vitamins and trace elements. Rifai N, Chiu RWK, Young I, eds: Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:chap 39.

8. Eliaz N. Corrosion of metallic biomaterials: A review. Materials (Basel). 2019;12(3):407. doi:10.3390/ma12030407

Day(s) Performed

Tuesday, Wednesday, Friday

Report Available

1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82495

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRWB Chromium, B 5619-2

 

Result ID Test Result Name Result LOINC Value
65601 Chromium, B 5619-2