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Test Code COUO Cobalt Occupational Exposure, Random, Urine


Ordering Guidance


High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.



Specimen Required


Supplies: Urine Tubes, 10 mL (T068)

Collection Container/Tube: Clean, plastic urine collection container

Submission Container/Tube: Plastic 10 mL urine tube or a clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 3 mL

Collection Instructions:

1. At the end of the work week, collect a random urine specimen at the end of the employee's work shift.

2. See Metals Analysis Specimen Collection and Transport for complete instructions.


Useful For

Screening for occupational exposure to cobalt

Profile Information

Test ID Reporting Name Available Separately Always Performed
CRETR Creatinine, Random, U No Yes
COUOE Cobalt Occupational Exposure, U No Yes

Method Name

CRETR: Enzymatic Colorimetric Assay

COUOE: Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Reporting Name

Cobalt Occupat Exp, Random, U

Specimen Type

Urine

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reference Values

COBALT:

0-17 years: Not established

≥18 years: The American Conference of Governmental Industrial Hygienists Biological Exposure Index for cobalt in urine is an end-of-shift concentration above14.9 mcg/L at the end of the work week.

 

CREATININE:

≥18 years old: 16-326 mg/dL

Reference values have not been established for patients who are younger than 18 years of age.

Interpretation

For occupational exposure, the sampling time is at the end of the shift at the end of the work week. The American Conference of Governmental Industrial Hygienists Biological Exposure Index for cobalt is a concentration of 15.0 mcg/L or above at the end of the work week.

Clinical Reference

1. Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. American Conference of Governmental Industrial Hygienists (ACGIH); 2010

2. U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry. Toxicology profile for cobalt. HHS; April 2004. Accessed October 17, 2023. Available at www.atsdr.cdc.gov/ToxProfiles/tp33.pdf

3. Lison D, De Boeck M, Verougstraete V, Kirsch-Volders M. Update on the genotoxicity and carcinogenicity of cobalt compounds. Occup Environ Med. 2001;58(10):619-625

4. Sodi R. Vitamins and trace elements. Rifai N, Chiu RWK, Young I, eds: Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:chap 39.

5. Crutsen JRW, Koper MC, Jelsma J, et al. Prosthetic hip-associated cobalt toxicity: a systematic review of case series and case reports. EFORT Open Rev. 2022;7(3):188-199

6. Leyssens L, Vinck B, Van Der Straeten C, Wuyts F, Maes L. Cobalt toxicity in humans-A review of the potential sources and systemic health effects. Toxicology. 2017;387:43-56. doi:10.1016/j.tox.2017.05.015

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83018

82570

LOINC Code Information

Test ID Test Order Name Order LOINC Value
COUO Cobalt Occupat Exp, Random, U 13468-4

 

Result ID Test Result Name Result LOINC Value
607763 Cobalt Occupational Exposure 13468-4
CRETR Creatinine, Random, U 2161-8
608389 Cobalt Concentration 5628-3

Day(s) Performed

Tuesday, Wednesday, Friday

Report Available

1 to 4 days