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Test Code CMVMS Cytomegalovirus Antibody, IgM, Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.6 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Aiding in the diagnosis of acute infection with cytomegalovirus

Method Name

Electrochemiluminescence Immunoassay (ECLIA)

Reporting Name

CMV Ab, IgM, S

Specimen Type

Serum

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  90 days
  Ambient  7 days

Reference Values

Negative

 

Reference values apply to all ages.

Interpretation

Negative:

No IgM to cytomegalovirus (CMV) detected. False negative results may occur in immunocompromised patients.

 

Borderline:

Recommend follow-up testing in 10 to 14 days if clinically indicated.

 

Positive:

CMV IgM antibodies detected, which may indicate active or recent infection. Low level IgM antibodies may persist for more than 12 months following disease resolution.

Clinical Reference

1. Bruminhent J, Thongprayoon C, Dierkhising RA, Kremers WK, Theel ES, Razonable RR. Risk factors for cytomegalovirus reactivation after liver transplantation: can pre-transplant cytomegalovirus antibody titers predict outcome?. Liver Transpl. 2015;21(4):539-546. doi:10.1002/lt.24078

2. Dioverti MV, Razonable RR. Cytomegalovirus. Microbiol Spectr. 2016;4(4):10.1128/microbiolspec.DMIH2-0022-2015. doi:10.1128/microbiolspec.DMIH2-0022-2015

3. Fowler K, Mucha J, Neumann M, et al. A systematic literature review of the global seroprevalence of cytomegalovirus: possible implications for treatment, screening, and vaccine development. BMC Public Health. 2022;22(1):1659. Published 2022 Sep 1. doi:10.1186/s12889-022-13971-7

4. Limaye AP, Babu TM, Boeckh M. Progress and challenges in the prevention, diagnosis, and management of cytomegalovirus infection in transplantation. Clin Microbiol Rev. 2020;34(1):e00043-19. Published 2020 Oct 28. doi:10.1128/CMR.00043-19

5. Leber AL. Maternal and congenital human cytomegalovirus infection: laboratory testing for detection and diagnosis [published correction appears in J Clin Microbiol. 2024 Sep 11;62(9):e0116424. doi: 10.1128/jcm.01164-24.]. J Clin Microbiol. 2024;62(4):e0031323. doi:10.1128/jcm.00313-23

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86645

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CMVMS CMV Ab, IgM, S 30325-5

 

Result ID Test Result Name Result LOINC Value
MCMV CMV Ab, IgM, S 30325-5