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Test Code CMVLR Cytomegalovirus (CMV) Molecular Detection, PCR, Lower Respiratory


Ordering Guidance


For plasma specimens, order CMVQN / Cytomegalovirus (CMV) DNA Detection and Quantification by Real-Time PCR, Plasma.



Necessary Information


Specimen source is required.



Specimen Required


Specimen Type: Lower respiratory

Source: Bronchial washing, bronchoalveolar lavage, fluid/washings from lung, sputum, tracheal secretions, tracheal aspirates

Container/Tube:

Preferred: Sterile, screwcap, 5-mL aliquot tube

Acceptable: Sterile container

Specimen Volume: 1 mL

Collection Instructions: Do not centrifuge.


Useful For

Rapid qualitative detection of cytomegalovirus (CMV) DNA in lower respiratory specimens

 

This test is not intended for the monitoring of CMV disease progression or response to therapy.

Method Name

Real-Time Polymerase Chain Reaction (PCR)/DNA Probe Hybridization

Reporting Name

Cytomegalovirus, PCR, Lower Resp

Specimen Type

Varies

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Varies Refrigerated (preferred) 7 days
  Frozen  7 days

Reference Values

Negative

 

Reference values apply to all ages.

Interpretation

A positive result indicates the presence of cytomegalovirus (CMV) DNA in the patient specimen.

 

A negative result indicates the absence of CMV DNA in the patient specimen but does not rule out possible infection with CMV.

 

An invalid result indicates the inability to conclusively determine presence or absence of CMV DNA in the patient specimen.

Clinical Reference

1. Caliendo, AM. Approach to the diagnosis of cytomegalovirus infection. UpToDate; Updated May 16, 2024. Accessed November 1, 2024. Available at www.uptodate.com/contents/approach-to-the-diagnosis-of-cytomegalovirus-infection

2. Fernholz EC, Vidal-Folch N, Hasadsri L. Rapid and direct detection of congenital cytomegalovirus using a commercial real-time PCR assay. J Clin Microbiol. 2023;61(3):e0178122. doi:10.1128/jcm.01781-22

3. Saksirisampant G, Kawamatawong T, Promsombat K, et al. A prospective study of plasma and bronchoalveolar lavage fluid CMV DNA load quantification for the diagnosis and outcome of CMV pneumonitis in immunocompromised hosts. J Clin Virol. 2022;155:105243. doi:10.1016/j.jcv.2022.105243

4. Setiabudi D, Sukur RR, Nugraha HG, Nataprawira HM. Cytomegalovirus pneumonitis in infants: The challenge in diagnosis among pediatricians. IDCases. 2023;32:e01724. doi:10.1016/j.idcr.2023.e01724

5. Prokop K, Schmitt B. Performance evaluation of a new CMV Direct PCR assay using urine, CSF and Bronchoalveolar lavage specimen types.ASM Clinical Virology Symposium. 09/11/2023

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

87496

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CMVLR Cytomegalovirus, PCR, Lower Resp 104760-4

 

Result ID Test Result Name Result LOINC Value
CMVSS Specimen Source 31208-2
621771 CMVLR, PCR 104760-4