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Test Code CL_F Chloride, Feces


Ordering Guidance


This test is only clinically valid if performed on watery specimens. In the event a formed fecal specimen is submitted, the test will not be performed.



Specimen Required


Patient Preparation: No barium, laxatives, or enemas may be used for 96 hours prior to start of, or during, collection.

Supplies: Stool containers - 24, 48, 72 Hour Kit (T291)

Container/Tube: Stool container

Specimen Volume: 10 g

Collection Instructions: Collect a very liquid stool specimen.


Useful For

Workup of cases of chronic diarrhea

 

Evaluation of suspected chloridorrhea 

Method Name

Indirect Ion-Selective Electrode (ISE) Potentiometry

Reporting Name

Chloride, F

Specimen Type

Fecal

Specimen Minimum Volume

5 g

Specimen Stability Information

Specimen Type Temperature Time Special Container
Fecal Frozen (preferred) 14 days
  Refrigerated  7 days
  Ambient  48 hours

Reference Values

An interpretive report will be provided

Interpretation

Fecal chloride may be low (<20 mmol/L) in sodium sulfate-induced diarrhea.(4)

 

Markedly elevated fecal chloride concentration in infants (>60 mmol/L) and adults (>100 mmol/L) is associated with congenital and secondary chloridorrhea.(5)

Clinical Reference

1. Steffer KJ, Santa Ana CA, Cole JA, Fordtran JS: The practical value of comprehensive stool analysis in detecting the cause of idiopathic chronic diarrhea. Gastroenterol Clin North Am 2012;41:539-560

2. Makela S, Kere J, Holmberg C, Hoglund P: SLC26A3 mutations in congenital chloride diarrhea. Hum Mutat. 2002 Dec;20(6):425-438. doi: 10.1002/humu.10139/

3. Ali OM, Shealy C, Saklayen M: Acute pre-renal failure: acquired chloride diarrhea after bowel resection. Clin Kidney J. 2012;5(4):356-358. doi: 10.1093/ckj/sfs082

4. Eherer AJ, Fordtran JS: Fecal osmotic gap and pH in experimental diarrhea of various causes. Gastroenterology. 1992;103:545-551

5. Casprary WF: Diarrhea associated with carbohydrate malabsorption. Clin Gastroenterol. 1986;15:631-655

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82438

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CL_F Chloride, F 15158-9

 

Result ID Test Result Name Result LOINC Value
CL_F Chloride, F 15158-9

Day(s) Performed

Monday, Thursday

Report Available

1 to 3 days