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Test Code CITR2 Citrate Concentration, Random, Urine


Specimen Required


Only orderable as part of a profile. For more information see CITRA / Citrate Excretion, Random, Urine.

 

Patient Preparation: Any drug that causes alkalemia or acidemia may be expected to alter citrate excretion and should be avoided, if possible. The patient must avoid laxative use for24 hours prior to collection.

Supplies: Sarstedt 5 mL Aliquot Tube (T914)

Container/Tube: Plastic, 5-mL tube

Specimen Volume: 4 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Useful For

Diagnosing risk factors for patients with calcium kidney stones

 

Monitoring results of therapy in patients with calcium stones or renal tubular acidosis

Method Name

Only orderable as part of a profile. For more information see CITRA / Citrate Excretion, Random, Urine. 

Reporting Name

Citrate Concentration, Random, U

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

Only orderable as part of a profile. For more information see CITRA / Citrate Excretion, Random, Urine.

 

No established reference values

Interpretation

A low citrate value represents a potential risk for kidney stone formation/growth. Patients with low urinary citrate and new or growing stone formation may benefit from adjustments in therapy known to increase urinary citrate excretion.

 

Very low citrate levels suggest investigation for the possible diagnosis of metabolic acidosis (eg, renal tubular acidosis).

 

For children ages 5 to 18, a ratio of less than 0.176 mg citrate/ mg creatinine is below the 5% reference range and considered low.(1)

Clinical Reference

1. Srivastava T, Winston MJ, Auron A et al: Urine calcium/citrate ratio in children with hypercalciuric stones. Pediatr Res. 2009;66:85-90

2. Hosking DH, Wilson JW, Liedtke RR, et al: The urinary excretion of citrate in normal persons and patients with idiopathic calcium urolithiasis (abstract). Urol Res. 1984;12:26

3. Lieske JC, Wang X: Heritable traits that contribute to nephrolithiasis. Urolithiasis. 2019 Feb;47(1):5-10

4. Lieske JC, Turner ST, Edeh SN, Smith JA, Kardia SLR: Heritability of urinary traits that contribute to nephrolithiasis. Clin J Am Soc Nephrol. 2014 May;9(5):943-950. doi: 10.2215/CJN.08210813

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 day

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82507

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CITR2 Citrate Concentration, Random, U 2128-7

 

Result ID Test Result Name Result LOINC Value
CITR2 Citrate Concentration, Random, U 2128-7