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Test Code CHIKV Chikungunya IgM and IgG, Antibody, Serum

Useful For

Aiding in the diagnosis of recent infection with Chikungunya virus in patients with recent travel to endemic areas and a compatible clinical syndrome

Profile Information

Test ID Reporting Name Available Separately Always Performed
CHIKM Chikungunya IgM, Ab, S No Yes
CHIKG Chikungunya IgG, Ab, S No Yes
CHIKI Chikungunya Interpretation No Yes

Method Name

CHIKM, CHIKG: Enzyme-Linked Immunosorbent Assay (ELISA)

CHIKI: Technical Interpretation

Reporting Name

Chikungunya IgM and IgG, Ab, S

Specimen Type

Serum


Ordering Guidance


Testing a patient in a convalescent period is recommended because specimens collected too early following infection may be negative for antibodies to Chikungunya virus.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 30 days
  Frozen  30 days

Reference Values

IgM: Negative

IgG: Negative

Reference values apply to all ages.

Interpretation

IgM and IgG Negative:

-No serologic evidence of exposure to Chikungunya virus. Repeat testing on a new specimen collected in 5 to 10 days is recommended if clinical suspicion persists.

 

IgM and IgG Positive:

-IgM and IgG antibodies to Chikungunya virus detected, suggesting recent or past infection. IgM antibodies to Chikungunya virus may remain detectable for 3 to 4 months post-infection.

 

IgM Positive, IgG Negative:

-IgM antibodies to Chikungunya virus detected, suggesting recent infection. Repeat testing in 5 to 10 days is recommended to demonstrate anti-Chikungunya virus IgG seroconversion to confirm current infection.

 

IgM Negative, IgG Positive:

-IgG antibodies to Chikungunya virus detected, suggesting past infection.

 

IgM and/or IgG Borderline:

-Repeat testing in 10 to 14 days is recommended.

Clinical Reference

Lwande OW, Obanda V, Bucht G, et al. Global emergence of Alphaviruses that cause arthritis in humans. Infect Ecol Epidemiol. 2015;5:29853. doi:10.3402/iee.v5.29853

Day(s) Performed

Bimonthly on the second and fourth Wednesday; fifth Wednesday when applicable

Report Available

Same day/1 to 14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86790 x2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CHIKV Chikungunya IgM and IgG, Ab, S 93976-9

 

Result ID Test Result Name Result LOINC Value
CHIKI Chikungunya Interpretation 69048-7
CHIKG Chikungunya IgG, Ab, S 88630-9
CHIKM Chikungunya IgM, Ab, S 88629-1

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.

Testing Algorithm

For more information see Mosquito-borne Disease Laboratory Testing.