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HelpTest Code CATPF Cat Epithelium, IgE, with Reflex to Cat Epithelium Components, IgE, Serum
Ordering Guidance
For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Evaluating patients with suspected cat allergy
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CATPR | Cat Epithelium Components, IgE, S | No | No |
Testing Algorithm
Testing begins with analysis of cat epithelium IgE. If cat epithelium IgE is negative (<0.10 kU/L), testing is complete.
If cat epithelium IgE is 0.10 kU/L or more, then 4 cat epithelium components (Fel d 1, Fel d 2, Fel d 4, Fel d 7) will be performed at an additional charge.
Special Instructions
Method Name
Fluorescent Enzyme Immunoassay (FEIA)
Reporting Name
Cat Epithelium Component Reflex, SSpecimen Type
SerumSpecimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days |
Reference Values
|
Class |
IgE kU/L |
Interpretation |
|
0 |
<0.10 |
Negative |
|
0/1 |
0.10-0.34 |
Borderline/equivocal |
|
1 |
0.35-0.69 |
Equivocal |
|
2 |
0.70-3.49 |
Positive |
|
3 |
3.50-17.4 |
Positive |
|
4 |
17.5-49.9 |
Strongly positive |
|
5 |
50.0-99.9 |
Strongly positive |
|
6 |
≥100 |
Strongly positive |
Concentrations of 0.70 kU/L or more (class 2 and above) will flag as abnormally high.
Reference values apply to all ages.
Interpretation
When detectable total cat epithelium IgE antibody is present (≥0.10 IgE kUa/L), additional specific component IgE antibody testing will be performed. If at least one potential specific allergenic cat component IgE is detected (≥0.10 IgE kUa/L), an interpretative report will be provided.
When the sample is negative for total cat epithelium IgE antibody (<0.10 IgE kUa/L), additional testing for specific cat component IgE antibodies will not be performed. Negative IgE results for total cat epithelium antibody may indicate a lack of sensitization to potential cat allergenic components.
Clinical Reference
1. Gronlund H, Adedoyin J, Reininger R, et al: Higher immunoglobulin E antibody levels to recombinant Fel d 1 in cat-allergic children with asthma compared with rhinoconjunctivitis. Clin Exp Allergy. 2008 Aug;38(8):1275-1281. doi: 10.1111/j.1365-2222.2008.03003.x
2. Nwaru BI, Suzuki S, Ekerljung L, et al: Furry animal allergen component sensitization and clinical outcomes in adult asthma and rhinitis. J Allergy Clin Immunol Pract. 2019 Apr;7(4):1230-1238.e4.
3. Davila I, Dominguez-Ortega J, Navarro-Pulido A, et al: Consensus document on dog and cat allergy. Allergy. 2018 Jun;73(6):1206-1222. doi: 10.1111/all.13391
4. Bjerg A, Winberg A, Berthold M, Mattsson L, Borres MP, Ronmark E: A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren. Pediatr Allergy Immunol. 2015 Sep;26(6):557-563
5. Konradsen JR, Fujisawa T, van Hage M, et al: Allergy to furry animals: New insights, diagnostic approaches, and challenges. J Allergy Clin Immunol. 2015;135(3):616-625
6. de Groot H, van Swieten P, Aalberse RC: Evidence for a Fel d I-like molecule in the "big cats" (Felidae species). J Allergy Clin Immunol. 1990;86(1):107-116
7. Bonnet B, Messaoudi K, Jacomet F, et al: An update on molecular cat allergens: Fel d 1 and what else? Chapter 1: Fel d 1, the major cat allergen. Allergy Asthma Clin Immunol. 2018 Apr 10;14:14. doi: 10.1186/s13223-018-0239-8
8. Bousquet PJ, Chinn S, Janson C, et al: Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey I. Allergy. 2007;62(3):301-309
9. Satyaraj E, Wedner HJ, Bousquet J: Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen. Allergy. 2019;74(S107):5-17 . doi: 10.1111/all.14013
10. Drouet M, Boutet S, Lauret MG, et al: [The pork-cat syndrome or crossed allergy between pork meat and cat epithelia (1)]. Allerg Immunol (Paris). 1994 May;26(5):166-168, 71-72
11. Huang Z, Zhu H, Lin R, et al: Serum albumin as a cross-reactive component in furry animals may be related to the allergic symptoms of patients with rhinitis. J Asthma Allergy. 2021 Oct 21;14:1231-1242. doi: 10.2147/JAA.S334195
12. Smith W, Butler AJ, Hazell LA, et al: Fel d 4, a cat lipocalin allergen. Clin Exp Allergy 2004;34(11):1732-8
Day(s) Performed
Monday through Friday
Report Available
Same day/1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86003
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CATPF | Cat Epithelium Component Reflex, S | 6833-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CAT1 | Cat Epithelium, IgE, S | 6833-8 |
Forms
If not ordering electronically, complete, print, and send an Allergen Test Request (T236) with the specimen.