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Test Code BMIPB Borrelia miyamotoi Detection, PCR, Blood


Ordering Guidance


This assay does not detect the Borrelia species that cause Lyme disease. If Lyme disease is suspected, order SLYME / Lyme Antibody Modified 2-Tier with Reflex, Serum.



Specimen Required


Container/Tube: Lavender top (EDTA)

Specimen Volume: 1 mL

Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.


Useful For

Aiding in the diagnosis of Borrelia miyamotoi infection in conjunction with clinical findings

 

Preferred method for detection of B miyamotoi using blood specimens

Testing Algorithm

For more information see Acute Tick-Borne Disease Testing Algorithm.

Method Name

Real-Time Polymerase Chain Reaction (PCR)

Reporting Name

Borrelia miyamotoi Detection, PCR, B

Specimen Type

Whole Blood EDTA

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Refrigerated 7 days

Reference Values

Negative

Reference values apply to all ages.

Interpretation

A positive result indicates the presence of Borrelia miyamotoi DNA and is consistent with active or recent infection. While positive results are highly specific indicators of disease, they should be correlated with symptoms and clinical findings of tick-borne relapsing fever.

Clinical Reference

1. Gugliotta JL, Goethert HK, Berardi VP, Telford SR III: Meningoencephalitis from Borrelia miyamotoi in an immunocompromised patient. N Engl J Med. 2013 Jan 17;368(3):240-245

2. Fomenko NV, Borgoyakov VY, Panov VV: Genetic features of DNA of Borrelia miyamotoi transmitted by Ixodes persulcatus. Mol Genet Microbiol Virol 2011;26:60-65. doi: 10.3103/S0891416811020054

3. Platonov AE, Karan LS, Kolyasnikova NM, et al: Humans Infected with Relapsing Fever Spirochete Borrelia miyamotoi, Russia. Emerg Infect Dis. 2011 Oct;17(10):1816-1823

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

87478

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BMIPB Borrelia miyamotoi Detection, PCR, B 82475-5

 

Result ID Test Result Name Result LOINC Value
618298 B. miyamotoi PCR, B 82475-5

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.