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Test Code BIWB Bismuth, Blood

Useful For

Determining bismuth toxicity

Method Name

Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

Reporting Name

Bismuth, B

Specimen Type

Whole blood


Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Metal Free B-D Tube (EDTA), 6 mL (T183)

Collection Container/Tube: Royal blue top (EDTA) plastic trace element blood collection tube

Specimen Volume: 0.8 mL

Collection Instructions:

1. See Metals Analysis Specimen Collection and Transport for complete instructions.

2. Send whole blood specimen in original tube. Do not aliquot.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

<1 ng/mL (unexposed)

4-30 ng/mL (therapeutic)

Interpretation

Normal blood concentrations for unexposed individuals are less than 1 ng/mL and the therapeutic range is 4 to 30 ng/mL.(2-5)

Clinical Reference

1. Baselt R. Disposition of Toxic Drugs and Chemicals In Man. 10th ed. Biomedical Publications; 2014

2. Heitland P, Koster HD. Biomonitoring of 37 trace elements in blood samples from inhabitants of northern Germany by ICP-MS. J Trace Elem Med Biol. 2006;20(4):253-262

3. Serfontein WJ, Mekel R, Bank S, Barbezat G, Novis B. Bismuth toxicity in man-I. Bismuth blood and urine levels in patients after administration of a bismuth protein complex (Bicitropeptide). Res Commun Chem Pathol Pharmacol. 1979;26(2):383-389

4. Serfontein WJ, Mekel R. Bismuth toxicity in man II. Review of bismuth blood and urine levels in patients after administration of therapeutic bismuth formulations in relation to the problem of bismuth toxicity in man. Res Commun Chem Pathol Pharmacol. 1979;26(2):391-411

5. Sodi R. Vitamins and trace elements. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:417-417

6. Keogan DM, Griffith DM. Current and potential applications of bismuth-based drugs. Molecules. 2014;19(9):15258-97. doi:10.3390/molecules190915258

Day(s) Performed

Wednesday

Report Available

1 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83018

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BIWB Bismuth, B 8161-2

 

Result ID Test Result Name Result LOINC Value
64274 Bismuth, B 8161-2