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HelpTest Code BHYPS Hypersensitivity Pneumonitis Panel, Immunoglobulin G, Serum
Ordering Guidance
This is a panel of tests which includes serology for: Alternaria tenuis/alternata, Aspergillus fumigatus, Aureobasidium pullulans, Laceyella sacchari, Micropolyspora faeni, Penicillium chrysogenum/notatum, Phoma betae, and Trichoderma viride. If only Aspergillus fumigatus is requested, order SASP / Aspergillus fumigatus, IgG Antibodies, Serum.
Specimen Required
Container/Tube: Sarstedt Aliquot Tube, 5 mL (T914)
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 0.5 mL Serum
Collection Information: Centrifuge and aliquot serum into a plastic vial.
Useful For
Evaluation of patients suspected of having hypersensitivity pneumonitis induced by exposure to Alternaria tenuis/alternata, Aspergillus fumigatus, Aureobasidium pullulans, Laceyella sacchari, Micropolyspora faeni, Penicillium chrysogenum/notatum, Phoma betae, and Trichoderma viride
Method Name
Fluorescence Enzyme Immunoassay (FEIA)
Reporting Name
Hypersensitivity Pheum Panel,IgG, SSpecimen Type
SerumSpecimen Minimum Volume
Serum: 0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 28 days |
Reference Values
Alternaria alternata, IgG antibody: ≤19.0 mg/L
Aspergillus fumigatus, IgG antibody: ≤102.0 mg/L
Aureobasidium pullulans, IgG antibody: ≤16.0 mg/L
Laceyella sacchari, IgG antibody: ≤45.0 mg/L
Micropolyspora faeni, IgG antibody: ≤6.0 mg/L
Penicillium chrysogenum, IgG antibody: ≤94.0 mg/L
Phoma betae, IgG antibody: ≤16.0 mg/L
Trichoderma viride, IgG antibody: ≤16.0 mg/L
Interpretation
Antibody levels greater than the reference range indicate that the patient has been immunologically sensitized to the antigen or a related antigen. The significance of an elevated antibody response is dependent on a combination of patient's clinical history, HRCT (high-resolution computed tomography) scan findings, pathological examination, and certain risk factors (eg, environmental and occupational determinants). Results must be interpreted as a component of a comprehensive diagnostic evaluation and known limitations of hypersensitivity tests.
Clinical Reference
1. Raghu G, Remy-Jardin M, Ryerson CJ, et al. Diagnosis of Hypersensitivity Pneumonitis in Adults. An Official ATS/JRS/ALAT Clinical Practice Guideline. Am J Respir Crit Care Med. 2020;202(3): e36-e69
2. Walsh SLF, Wells AU, Desai SR, et al. Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study. Lancet Respir Med. 2016;4(7):557-565
3. Barnes H, Troy L, Lee CT, Sperling A, Strek M, Glaspole I. Hypersensitivity pneumonitis: Current concepts in pathogenesis, diagnosis, and treatment. Allergy. 2022;77(2):442-453
4. Jenkins AR, Chua A, Chami H, et al. Questionnaires or Serum Immunoglobulin G Testing in the Diagnosis of Hypersensitivity Pneumonitis among Patients with Interstitial Lung Disease. Ann Am Thorac Soc. 2021;18(1):130-147
5. Johannson KA, Barnes H, Bellanger AP, et al. Exposure Assessment Tools for Hypersensitivity Pneumonitis. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2020:17(12):1501-1509
6. Kongsupon N, Walters GI, Sadhra SS. Occupational causes of hypersensitivity pneumonitis: a systematic review and compendium. Occup Med (Lond). 2021;71(6-7):255-259
7. Calaras D, David A, Vasarmidi E, Antoniou K, Corlateanu A. Hypersensitivity Pneumonitis: Challenges of a Complex Disease. Can Resp J. 2024;2024:4919951
8. Barnes H, Lu J, Glaspole I, Collard HR, Johannson KA. Exposures and associations with clinical phenotypes in hypersensitivity pneumonitis: A scoping review. Respir Med. 2021;184:106444
9. Raulf, M, et al. Update of reference values for IgG antibodies against typical antigens of hypersensitivity pneumonitis: Data of a German multicentre study. Allergo Jour Int. 2019;28(6):192-203
10. Lozier B, Martins T, Slev P, Saadalla A. Determination of Positivity Cutoff for an Automated Aspergillus fumigatus-Specific Immunoglobulin-G Assay in a National Reference Laboratory. J Appl Lab Med. 2025;10(3): 619-628
Day(s) Performed
Monday through Friday
Report Available
2 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
86001 x 8
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| BHYPS | Hypersensitivity Pheum Panel,IgG, S | 35577-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| BH01 | Alternaria alternata, IgG Ab | 26951-4 |
| BH02 | Aspergillus fumigatus, IgG Ab | 26954-8 |
| BH03 | Aureobasidium pullulans, IgG Ab | 26955-5 |
| BH04 | Laceyella sacchari, IgG Ab | 105270-3 |
| BH05 | Micropolyspora faeni, IgG Ab | 26948-0 |
| BH06 | Penicillium chrysogenum, IgG Ab | 26957-1 |
| BH07 | Phoma betae, IgG Ab | 35551-1 |
| BH08 | Trichoderma viride, IgG Ab | 49687-7 |
| BH09 | Hypersensitivity Interpretation | 69048-7 |