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Test Code BFBL Bilirubin, Body Fluid

Reporting Name

Bilirubin, BF

Useful For

Evaluating peritoneal fluid or abdominal drain fluid as a screening test for bile leakage

 

May aid in the distinction between a transudative and an exudative pleural effusion

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Body Fluid


Ordering Guidance


For bilirubin testing on urine specimens, order BILUR / Bilirubin, Random, Urine. Testing will be changed to BILUR if this test is ordered on urine specimens.



Shipping Instructions


Ship specimen in amber vial to protect from light.



Necessary Information


1. Date and time of collection are required.

2. Specimen source is required.



Specimen Required


Supplies: Amber Frosted Tube, 5 mL (T915)

Preferred Source:

-Peritoneal fluid (peritoneal, abdominal, ascites, paracentesis)

-Pleural fluid (pleural, chest, thoracentesis)

-Drain fluid (drainage, Jackson Pratt [JP] drain)

-Pericardial fluid

Acceptable Source: Other body fluid, write in source name with source location (if appropriate)

Collection Container/Tube: Sterile container

Submission Container/Tube: Opaque, amber vial

Specimen Volume: 1 mL

Collection Instructions:

1. Centrifuge to remove any cellular material and transfer into an amber vial to protect from light.

2. Indicate the specimen source and source location on label.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Body Fluid Frozen (preferred) 70 days LIGHT PROTECTED
  Refrigerated  14 days LIGHT PROTECTED

Reference Values

An interpretive report will be provided.

Day(s) Performed

Monday through Sunday

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82247

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BFBL Bilirubin, BF 1974-5

 

Result ID Test Result Name Result LOINC Value
BRNBF Bilirubin (BF) 1974-5
FLD14 Fluid Type: 14725-6

Interpretation

Bilirubin may be measured in other fluids although the decision limits are not well defined in fluids other than pleural fluid. Fluid to serum bilirubin ratios are expected to be less than or equal to 1.0 and should be interpreted in conjunction with other clinical findings.

Clinical Reference

1. Runyon BA. Ascitic fluid bilirubin concentration as a key to choleperitoneum. J Clin Gastroenterol. 1987;9(5):543-545

2. Koch M, Garden OJ, Padbury R, et al. Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery. Surgery 2011;149(5):680-688. doi:10.1016/j.surg.2010.12.002

3. Darwin P, Goldberg E, Uradomo L. Jackson Pratt drain fluid-to-serum bilirubin concentration ratio for the diagnosis of bile leaks. Gastrointest Endosc. 2010;71(1):99-104. doi:10.1016/j.gie.2009.08.015

4. Metintas M, Alatas O, Alatas F, Colak O, Ozdemir N, Erginel S. Comparative analysis of biochemical parameters for differentiation of pleural exudates from transudates Light's criteria, cholesterol, bilirubin, albumin gradient, alkaline phosphatase, creatine kinase, and uric acid. Clin Chim Acta. 1997;264(2):149-162. doi:10.1016/s0009-8981(97)00091-0

5. Block DR, Lasho MA, Donato, LJ, Meeusen JW. Establishing hemolysis, icterus, and lipemia interference limits for body fluid chemistry analytes measured on the Roche cobas instrument. AM J Clin Pathol. 2024:aqae040. doi: 10.1093/ajcp/aqae040

Report Available

Same day/1 to 2 days

Method Name

Photometric, Diazonium Salt