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Test Code BART Bartonella Antibody Panel, IgG and IgM, Serum

Reporting Name

Bartonella Ab Panel, IgG and IgM

Useful For

Diagnosis of Bartonella infection, especially in the context of a cat scratch

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

0.15 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 30 days
  Frozen  30 days

Reference Values

BARTONELLA HENSELAE

IgG: <1:128

IgM: <1:20

 

BARTONELLA QUINTANA

IgG: <1:128

IgM: <1:20

Day(s) Performed

Monday through Saturday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86611 x 4

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BART Bartonella Ab Panel, IgG and IgM 90251-0

 

Result ID Test Result Name Result LOINC Value
15659 Bart Henselae IgG In Process
15660 Bart Henselae IgM In Process
15661 Bart Quintana IgG In Process
15662 Bart Quintana IgM In Process

Interpretation

A positive immunofluorescence assay (IFA) IgM (titer >1:20) suggests a current infection with either Bartonella henselae or Bartonella quintana.

 

A positive IgG (titer >1:128) suggests a current or previous infection. Increases in IgG titers in serial specimens suggest active infection.

 

Normal serum specimens usually have an IgG titer of less than 1:128. However, 5% to 10% of healthy controls exhibit a B henselae and B quintana titer of 1:128. Sera from healthy volunteers rarely show titers of 1:256 or greater. IgM titers in normal serum are typically less than 1:20. IgM titers at 1:20 or greater have not been seen in the normal population.

 

Molecular testing of tissue for Bartonella species nucleic acid is recommended in cases of suspected endocarditis.

Clinical Reference

1. Rodino KG, Stone E, Saleh OA, Theel ES. The Brief case: Bartonella henselae endocarditis-a case of delayed diagnosis. J Clin Microbiol. 2019;57(9). e00114-19. doi:10.1128/JCM.00114-19

2. Wolf LA, Cherry NA, Maggi RG, Breitschwerdt EB. In pursuit of a stealth pathogen: Laboratory diagnosis of bartonellosis. Clin Micro News. 2014;36(5):33-39

Report Available

Same day/1 to 3 days

Method Name

Immunofluorescence Assay (IFA)

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.