Sign in →

Test Code B2MU Beta-2 Microglobulin, Random, Urine


Specimen Required


Patient Preparation: For 12 hours before specimen collection, do not take multivitamins or dietary supplements containing biotin (vitamin B7) which is commonly found in hair, skin, and nail supplements and multivitamins.

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Container/Tube: Plastic, urine tube

Specimen Volume: 1.0 mL

Collection Instructions:

1. Patient should empty bladder.

2. Have patient drink at least 0.5 liters of water.

3. Within 1 hour, collect a random urine specimen.

4. Add 1 M sodium hydroxide (NaOH) as preservative to the collection. This preservative is intended to achieve an approximate pH of between 6 and 8.


Useful For

Evaluation of renal tubular damage

 

Monitoring exposure to cadmium and mercury

Method Name

Automated Chemiluminescent Immunometric Assay

Reporting Name

Beta-2 Microglobulin, U

Specimen Type

Urine

Specimen Minimum Volume

0.5mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen (preferred) 14 days
  Refrigerated  48 hours

Reference Values

≤300 mcg/L

Interpretation

Increased excretion is consistent with renal tubular damage.

 

Beta-2 microglobulin excretion is increased 100 to 1000 times the upper limit of the reference interval in cadmium-exposed workers.

Clinical Reference

1. Ikeda M, Ezaki T, Tsukahara T, et al. Threshold levels of urinary cadmium in relation to increases in urinary beta2-microglobulin among general Japanese populations. Toxicol Lett. 2003;137(3):135-141

2. Moriguchi J, Ezaki T, Tsukahara T, et al. Comparative evaluation of four urinary tubular dysfunction markers, with special references to the effects of aging and correction for creatinine concentration. Toxicol Lett. 2003;143(3):279-290

3. Stefanovic V, Cukuranovic R, Mitic-Zlatkovic M, Hall PW. Increased urinary albumin excretion in children from families with Balkan nephropathy. Pediatr Nephrol. 2002;17(11):913-916

4. Assounga AG. Beta 2 microglobulin in kidney failure: A review and an algorithm for renal replacement therapy. Saudi J Kidney Dis Transpl. 2021;32(5):1214-1220. doi:10.4103/1319-2442.344740

5. Khanijou V, Zafari N, Coughlan MT, MacIsaac RJ, Ekinci EI. Review of potential biomarkers of inflammation and kidney injury in diabetic kidney disease. Diabetes Metab Res Rev. 2022;38(6):e3556. doi:10.1002/dmrr.3556

Day(s) Performed

Monday, Wednesday, Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82232

LOINC Code Information

Test ID Test Order Name Order LOINC Value
B2MU Beta-2 Microglobulin, U 1953-9

 

Result ID Test Result Name Result LOINC Value
B2MU Beta-2 Microglobulin, U 1953-9

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.