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HelpTest Code B2MC Beta-2-Microglobulin (Beta-2-M), Spinal Fluid
Reporting Name
Beta-2-Microglobulin, CSFUseful For
Evaluation of central nervous system inflammation and B-cell proliferative diseases
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
CSFSpecimen Required
Container/Tube: Sterile vial
Specimen Volume: 1 mL
Collection Instructions: Send spinal fluid from collection vial 1.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 14 days |
Reference Values
0.70-1.80 mcg/mL
Day(s) Performed
Monday through Friday
Test Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82232
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| B2MC | Beta-2-Microglobulin, CSF | 1951-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| B2MC | Beta-2-Microglobulin, CSF | 1951-3 |
Interpretation
Elevations of cerebrospinal fluid beta-2-microgobulin levels may be seen in a number of diseases including malignancies, autoimmune disease, and neurological disorders.
Clinical Reference
1. Koch TR, Lichtenfeld KM, Wiernik PH: Detection of central nervous system metastasis with cerebrospinal fluid beta-2-microglobulin. Cancer. 1983 Jul;52(1):101-104
2. Mavligit GM, Stuckey SE, Cabanillas FF, et al: Diagnosis of leukemia or lymphoma in the central nervous system by beta-2-microglobulin determination. N Engl J Med. 1980 Sep 25;303(13):718-722
3. Jeffery GM, Frampton CM, Legge HM, Hart DN: Cerebrospinal fluid beta 2-microglobulin levels in meningeal involvement by malignancy. Pathology. 1990 Jan;22(1):20-23
4. Us O, Lolli F, Baig S, Link H: Intrathecal synthesis of beta-2-microglobulin in multiple sclerosis and aseptic meningo-encephalitis. Acta Neurol Scand. 1989 Dec;80(6):598-602
5. Elovaara I, Livanainen M, Poutianen E, et al: CSF and serum beta-2-microglobulin in HIV infection related to neurological dysfunction. Acta Neurol Scand. 1989 Feb;79(2):81-87
6. Dolan MJ, Lucey DR, Hendrix CW, Melcher GP, Spencer GA, Boswell RN: Early markers of HIV infection and subclinical disease progression. Vaccine. 1993;11(5):548-551
7. Brew BJ, Bhalla RB, Fleisher M, et al: Cerebrospinal fluid beta 2 microglobulin in patients infected with human immunodeficiency virus. Neurology. 1989 Jun;39(6):830-834
8. Musto P, Tomasi P, Cascavilla N, et al: Significance and limits of cerebrospinal fluid beta-2-microglobulin measurement in course of acute lymphoblastic leukemia. Am J Hematol. 1988 Aug;28(4):213-218
9. Lucey DR, McGuire SA, Clerici M, et al: Comparison of spinal fluid beta 2-microglobulin levels with CD4+ T cell count, in vitro T helper cell function, and spinal fluid IgG parameters in 163 neurologically normal adults infected with the human immunodeficiency virus type l. J Infect Dis. 1991 May;163(5):971-975
10. Bjerrum OW, Bach FW, Zeeberg I: Increased level of cerebrospinal fluid beta 2-microglobulin is related to neurologic impairment in multiple sclerosis. Acta Neurol Scand. 1988 Jul;78(1):72-75
11. Dietzen DJ, Willrich MAV: Amino acids, peptides, and proteins. In: Rifai N, Chiu RWK, Young I, Burnham CAD, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:chap 31
Report Available
1 to 3 daysMethod Name
Nephelometry