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Test Code ASPAG Aspergillus (Galactomannan) Antigen, Serum

Reporting Name

Aspergillus Ag, S

Useful For

Aiding in the diagnosis of invasive aspergillosis

 

Assessing response to therapy

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum SST


Ordering Guidance


For bronchoalveolar lavage specimens, order ASPBA / Aspergillus Antigen, Bronchoalveolar Lavage.



Specimen Required


Container/Tube: Serum gel (red-top tubes are not acceptable)

Specimen Volume: 1.5 mL

Collection Instructions:

1. Avoid exposure of specimen to atmosphere to prevent sample contamination from environment.

2. Centrifuge and send specimen in original tube. Do not aliquot or open tube.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum SST Refrigerated (preferred) 14 days SERUM GEL TUBE
  Frozen  14 days SERUM GEL TUBE

Reference Values

<0.5 index

Reference values apply to all ages.

Day(s) Performed

Monday through Friday, Sunday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

87305 

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ASPAG Aspergillus Ag, S 44357-2

 

Result ID Test Result Name Result LOINC Value
84356 Aspergillus Ag, S 44357-2

Interpretation

A positive result supports a diagnosis of invasive aspergillosis (IA). Positive results should be considered in conjunction with other diagnostic procedures, such as microbiologic culture, histological examination of biopsy specimens, and radiographic evidence. See Cautions.

 

A negative result does not rule out the diagnosis of IA. Repeat testing is recommended if the result is negative but IA is clinically suspected. Patients at risk of IA should have a baseline serum tested and should be monitored twice a week for increasing galactomannan antigen levels.

 

Galactomannan antigen levels may be useful in the assessment of therapeutic response. Antigen levels decline in response to antimicrobial therapy.

Clinical Reference

1. Maertens J, Verhaegen J, Lagrou K, Boogaerts M: Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective evaluation. Blood. 2001 March 15;97(6):1604-1610

2. Pinel C, Fricker-Hidalgo H, Lebeau B, et al: Detection of circulating Aspergillus fumigatus galactomannan: value and limits of the Platelia test for diagnosing invasive aspergillosis. J Clin Microbiol. 2003 May;41(5):2184-2186

3. Swanink CM, Meis JF, Rijs AJ, Donnelly JP, Verweij PE: Specificity of a sandwich enzyme-linked immunosorbent assay for detecting Aspergillus galactomannan. J Clin Microbiol. 1997 Jan;35(1):257-260

4. Ansorg R, van den Boom R, Rath PM: Detection of Aspergillus galactomannan antigen in foods and antibiotics. Mycoses. 1997 Dec;40(9-10):353-357

5. Connolly P, Durkin M, Wheat LJ, et al: Rapid diagnosis of systemic and invasive mycoses. Clinical Microbiology Newsletter. 2007 Jan;29(1):1-5

6. Thompson GR, Patterson TF: Aspergillus species. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:3103-3116

Report Available

1 to 4 days

Method Name

Enzyme Immunoassay (EIA)