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HelpTest Code ARBOP Arbovirus Antibody Panel, IgG and IgM, Serum
Useful For
Aiding the diagnosis of arboviral encephalitis (California [LaCrosse], St. Louis, Eastern equine, and Western equine encephalitis)
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CAVP | Calif Virus (LaCrosse)IgG and IgM,S | Yes | Yes |
| EEEP | East Equine Enceph Ab, IgG and IgM, S | Yes | Yes |
| STLP | St. Louis Enceph Ab, IgG and IgM, S | Yes | Yes |
| WEEP | West Equine Enceph Ab,IgG and IgM,S | Yes | Yes |
Method Name
Immunofluorescence Assay (IFA)
Reporting Name
Arbovirus Ab Panel IgG and IgM, SSpecimen Type
SerumOrdering Guidance
This panel tests for 4 arboviruses; to test for a specific arbovirus, the following tests are individually orderable:
-CAVP / California Virus (La Crosse) IgG and IgM, Serum
-EEEP / Eastern Equine Encephalitis Antibody, IgG and IgM, Serum
-STLP / St. Louis Encephalitis Antibody, IgG and IgM, Serum
-WEEP / Western Equine Encephalitis Antibody, IgG and IgM, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
Specimen Minimum Volume
0.15 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reference Values
CALIFORNIA VIRUS (La CROSSE) ENCEPHALITIS ANTIBODY
IgG: <1:10
IgM: <1:10
Reference values apply to all ages.
EASTERN EQUINE ENCEPHALITIS ANTIBODY
IgG: <1:10
IgM: <1:10
Reference values apply to all ages.
ST. LOUIS ENCEPHALITIS ANTIBODY
IgG: <1:10
IgM: <1:10
Reference values apply to all ages.
WESTERN EQUINE ENCEPHALITIS
IgG: <1:10
IgM: <1:10
Reference values apply to all ages.
Interpretation
In patients infected with these or related viruses, IgM class antibody is reliably detected within 1 to 3 weeks of onset, peaking and rapidly declining within 3 months. Results from a single serum specimen can differentiate early (acute) infection from past infection with immunity if IgM is positive (suggests acute infection).
IgG antibody is generally detectable within 1 to 3 weeks of onset, peaking within 1 to 2 months, and declining slowly thereafter. A single serum specimen IgG of 1:10 or greater indicates exposure to the virus. A 4-fold or greater rise in IgG antibody titer in acute and convalescent sera indicates recent infection.
In the United States, it is unusual for any patient to show positive reactions to more than 1 of the arboviral antigens, although Western equine encephalitis and Eastern equine encephalitis antigens will show a noticeable cross-reactivity.
Clinical Reference
1. Gonzalez-Scarano F, Nathanson N. Bunyaviruses. In: Fields BN, Knipe DM, eds. Fields Virology. Vol 1. 2nd ed. Raven Press; 1990:1195-1228
2. Donat JF, Rhodes KH, Groover RV, Smith TF. Etiology and outcome in 42 children with acute nonbacterial meningoencephalitis. Mayo Clin Proc. 1980;55(3):156-160
3. Tsai TF. Arboviruses. In: Murray PR, Baron EJ, Pfaller MA, et al, eds. Manual of Clinical Microbiology. 7th ed. American Society for Microbiology; 1999:1107-1124
4. Calisher CH. Medically important arboviruses of the United States and Canada. Clin Microbiol Rev. 1994;7(1):89-116
5. Dolin R. California encephalitis, hantavirus pulmonary syndrome, hantavirus hemorrhagic fever with renal syndrome, and bunyavirus hemorrhagic fevers. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:2169-2176
Day(s) Performed
Monday through Friday
Report Available
Same day/1 to 4 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
86651 x 2-California virus (La Crosse) encephalitis antibody, IgG and IgM
86652 x 2-Eastern equine encephalitis antibody, IgG and IgM
86653 x 2-St. Louis encephalitis antibody, IgG and IgM
86654 x 2-Western equine encephalitis antibody, IgG and IgM
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ARBOP | Arbovirus Ab Panel IgG and IgM, S | 49093-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8764 | Calif (LaCrosse) Encep Ab, IgG, S | In Process |
| 83354 | East Equine Enceph Ab, IgG, S | In Process |
| 8182 | St. Louis Enceph Ab, IgG, S | In Process |
| 8193 | West Equine Enceph Ab, IgG, S | 6957-5 |
| 87279 | West Equine Enceph Ab, IgM, S | In Process |
| 87268 | St. Louis Enceph Ab, IgM, S | In Process |
| 83355 | East Equine Enceph Ab, IgM, S | In Process |
| 87280 | Calif (LaCrosse) Encep Ab, IgM, S | In Process |
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.