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Test Code ANAP Anaplasma phagocytophilum (Human Granulocytic Ehrlichiosis) Antibody, Serum

Reporting Name

Anaplasma phagocytophilum Ab, IgG,S

Useful For

As an adjunct in the diagnosis of human granulocytic ehrlichiosis (anaplasmosis)

 

Seroepidemiological surveys of the prevalence of the infection in certain populations

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

<1:64

Reference values apply to all ages.

Day(s) Performed

Monday through Friday

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86666

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ANAP Anaplasma phagocytophilum Ab, IgG,S 23877-4

 

Result ID Test Result Name Result LOINC Value
81157 Anaplasma phagocytophilum Ab, IgG,S 23877-4

Testing Algorithm

For more information see Acute Tick-Borne Disease Testing Algorithm.

Interpretation

A positive result of an immunofluorescence assay (IFA) test (titer ≥1:64) suggests current or previous infection with human granulocytic ehrlichiosis (anaplasmosis). In general, the higher the titer, the more likely it is that the patient has an active infection.

 

Seroconversion may also be demonstrated by a significant increase in IFA titers.

 

During the acute phase of the infection, serologic tests are often nonreactive, polymerase chain reaction (PCR) testing is available to aid in the diagnosis of these cases (see EPCRB / Ehrlichia/Anaplasma, Molecular Detection, PCR, Blood).

Clinical Reference

Center for Disease Control and Prevention (CDC): Tickborne Diseases of the United States: A Reference Manual for Healthcare Providers. 6th ed. US Department of Health and Human Services; 2022. Accessed May 10, 2024. Available at www.cdc.gov/ticks/tickbornediseases/TickborneDiseases-P.pdf

Report Available

1 to 3 days

Method Name

Immunofluorescence Assay (IFA)

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.