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HelpTest Code AMPHM Amphetamine-Type Stimulants Confirmation, Meconium
Reporting Name
Amphetamines, Confirmation, MUseful For
Detecting in utero exposure to amphetamine-type stimulants up to 5 months before birth
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
MeconiumOrdering Guidance
For chain-of-custody testing, order AMPMX / Amphetamine-Type Stimulants Confirmation, Chain of Custody, Meconium.
Specimen Required
Supplies: Stool container, Small (Random), 4 oz (T288)
Container/Tube: Stool container
Specimen Volume: 1 g (approximately 1 teaspoon)
Collection Instructions: Collect entire random meconium specimen.
Specimen Minimum Volume
0.3 g (approximately 1/4 teaspoon)
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Meconium | Frozen (preferred) | 28 days | |
| Ambient | 28 days | ||
| Refrigerated | 28 days |
Reference Values
Negative
Positives are reported with a quantitative liquid chromatography tandem mass spectrometry (LC-MS/MS) result.
Cutoff concentrations for LC-MS/MS testing:
Amphetamine: 20 ng/g
Methamphetamine: 20 ng/g
3,4-Methylenedioxyamphetamine: 20 ng/g
3,4-Methylenedioxyethylamphetamine: 20 ng/g
3,4-Methylenedioxymethamphetamine: 20 ng/g
Day(s) Performed
Monday through Sunday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80324
80359
G0480 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| AMPHM | Amphetamines, Confirmation, M | 69021-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 31854 | Amphetamine | 43934-9 |
| 31855 | Methamphetamine | 69022-2 |
| 31856 | 3,4-methylenedioxyamphetamine | 69023-0 |
| 31858 | 3,4-methylenedioxyethylamphetamine | 69024-8 |
| 31857 | 3,4-methylenedioxymethamphetamine | 69025-5 |
| 31882 | Interpretation | 69050-3 |
| 31883 | Chain of Custody | 77202-0 |
Interpretation
The presence of any of the following: amphetamine; methamphetamine; 3,4-methylenedioxyamphetamine; 3,4-methylenedioxymethamphetamine; or 3,4-methylenedioxyethylamphetamine at greater than 20 ng/g is indicative of in utero exposure up to 5 months before birth.
Clinical Reference
1. Baselt RC: Disposition of Toxic Drugs and Chemical in Man. 8th ed. Biochemical Publications; 2008:83-86; 947-952; 993-999
2. Ostrea EM Jr, Brady MJ, Parks PM, Asensio DC, Naluz: Drug screening of meconium in infants of drug-dependent mothers: an alternative to urine testing. J Pediatr. 1989 Sep;115(3):474-477
3. Ahanya SN, Lakshmanan J, Morgan BL, Ross MG: Meconium passage in utero: mechanisms, consequences, and management. Obstet Gynecol Surv. 2005 Jan;60(1):45-56
4. Kwong TC, Ryan RM: Detection of intrauterine illicit drug exposure by newborn drug testing. National Academy of Clinical Biochemistry. Clin Chem. 1997 Jan;43(1):235-242
5. Dixon SD: Effects of transplacental exposure to cocaine and methamphetamine on the neonate. West J Med. 1989 Apr;150(4):436-442
Report Available
2 to 3 daysMethod Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.