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HelpTest Code AHDV Hepatitis D Virus Total Antibodies, Serum
Necessary Information
Date of collection is required.
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Centrifuge blood collection tube per collection tube manufacturer's instructions (eg, centrifuge and aliquot within 2 hours of collection for BD Vacutainer tubes).
2. Aliquot serum into plastic vial.
Useful For
Detection of hepatitis D virus (HDV)-specific total antibodies (combined IgG and IgM) in human serum
Diagnosis of concurrent HDV infection in patients with fulminant acute hepatitis B virus (HBV) infection (acute coinfection), chronic HBV infection (chronic coinfection), or acute exacerbation of known chronic HBV infection (HDV superinfection)
Special Instructions
Method Name
Enzyme Immunoassay (EIA)
Reporting Name
HDV Total Ab, SSpecimen Type
SerumSpecimen Minimum Volume
0.25 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Frozen (preferred) | 30 days | |
| Refrigerated | 30 days |
Reference Values
Negative
Interpretation
This assay detects the presence of hepatitis D virus (HDV)-specific total (combined IgG and IgM) antibodies in serum.
Negative results indicate the absence of HDV infection and no past exposure to HDV.
Equivocal results indicate borderline level of anti-HDV total antibodies. Repeat testing in 1 to 2 weeks is recommended to determine the definitive HDV infection status.
Positive results usually indicate simultaneous acute or chronic coinfection with hepatitis B virus (HBV) and HDV; acute HDV infection in patients with known chronic HBV infection (ie, HDV superinfection); or resolved HDV infection. Results should be correlated with medical history and clinical findings.
For more information, see Viral Hepatitis Serologic Profiles.
Clinical Reference
1. Olivero A, Smedile A: Hepatitis delta virus diagnosis. Semin Liver Dis. 2012 Aug;32(3):220-227
2. Shah PA, Choudhry S, Reyes KJC, Lau DTY: An update on the management of chronic hepatitis D. Gastroenterol Rpt (Oxf). 2019 Oct;7(6):396-402. doi: 10.1093/gastro/goz052
3. Chen LY, Pang XY, Goyal H, et al: Hepatitis D: challenges in the estimation of true prevalence and laboratory diagnosis. Gut Pathog. 2021 Oct;13(1):66. doi. 10.1186/s13099-021-00462-0
Day(s) Performed
Monday, Friday
Report Available
1 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
86692
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| AHDV | HDV Total Ab, S | 40727-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 9209 | HDV Total Ab, S | 40727-0 |
Forms
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