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Test Code ADMI ADAMTS13 Interpretation


Specimen Required


Only orderable as part of a profile. For more information see ADAMP / ADAMTS13 Activity with Reflex Inhibitor Profile, Plasma.


Useful For

Technical interpretation of testing performed to assist in the diagnosis of congenital, immune, or acquired thrombotic thrombocytopenic purpura

Method Name

Only orderable as part of profile. For more information see ADAMP / ADAMTS13 Activity with Reflex Inhibitor Profile, Plasma

 

Technical Interpretation

Reporting Name

ADAMTS13 Interpretation

Specimen Type

Plasma Na Cit

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen

Reference Values

Only orderable as part of profile. For more information see ADAMP / ADAMTS13 Activity with Reflex Inhibitor Profile, Plasma.

 

ADAMTS13 ACTIVITY ASSAY

≥70%

ADMTS13 INHIBITOR TITER

<0.5 BU

Interpretation

Interpretive comments are provided.

 

Less than 10% ADAMTS13 activity is highly indicative of thrombotic thrombocytopenic purpura (TTP) in an appropriate clinical setting.

Clinical Reference

1. Sadler JE. Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura. Blood. 2008;112(1):11-18. doi.org/10.1182/blood-2008-02-078170

2. George JN. How I treat patients with thrombotic thrombocytopenic purpura: 2010. Blood. 2010;116(20):4060-4069. doi:10.1182/blood-2010-07-271445

3. Upshaw JD: Congenital deficiency of a factor in normal plasma that reverses microangiopathic hemolysis and thrombocytopenia. N Engl J Med. 1978;298(24):1350-1352. doi:10.1056/NEJM197806152982407

4. Chiasakul T, Cuker A. Clinical and laboratory diagnosis of TTP: an integrated approach. Hematology Am Soc Hematol Educ Program. 2018;2018(1):530-538. doi:10.1182/asheducation-2018.1.530

5. Mackie I, Mancini I, Muia J, et al. International Council for Standardization in Haematology (ICSH) recommendations for laboratory measurement of ADAMTS13. Int J Lab Hematol. 2020;42(6):685-696. doi:10.1111/ijlh.13295

Day(s) Performed

Monday through Sunday

Report Available

3 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

Not Applicable

LOINC Code Information

Result ID Test Result Name Result LOINC Value
621149 ADAMTS13 Interpretation 69049-5
621150 ADAMTS13 Interpretation No LOINC Needed