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Test Code AAT Alpha-1-Antitrypsin, Serum

Reporting Name

Alpha-1-Antitrypsin, S

Useful For

Workup of individuals with suspected disorders such as familial chronic obstructive lung disease

 

Diagnosing alpha-1-antitrypsin deficiency

Testing Algorithm

For more information see Alpha-1-Antitrypsin-A Comprehensive Testing Algorithm.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

100-190 mg/dL

Day(s) Performed

Monday through Friday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82103

LOINC Code Information

Test ID Test Order Name Order LOINC Value
AAT Alpha-1-Antitrypsin, S 6771-0

 

Result ID Test Result Name Result LOINC Value
AAT Alpha-1-Antitrypsin, S 6771-0

Interpretation

Patients with serum levels less than 70 mg/dL may have a homozygous deficiency and are at risk for early lung disease. Alpha-1-antitrypsin proteotype testing should be done to confirm the presence of homozygous deficiency alleles.

 

If clinically indicated, patients with serum levels less than 125 mg/dL should have proteotype testing in order to identify heterozygous individuals. Heterozygotes do not appear to be at increased risk for early emphysema.

Clinical Reference

1. Tejwani V, Stoller JK: The spectrum of clinical sequelae associated with alpha-1 antitrypsin deficiency. Ther Adv Chronic Dis. 2021 Jul;12_suppl. doi: 10.1177/2040622321995691

2. Patel D, McAllister SL, Teckman JH: Alpha-1 antitrypsin deficiency liver disease. Transl Gastroenterol Hepatol. 2021 Apr 5;6:23. doi: 10.21037/tgh.2020.02.23

3. Donato LJ, Snyder MR, Greene DN: Measuring and interpreting serum AAT concentration. Methods Mol Biol. 2017;1639:21-32. doi: 10.1007/978-1-4939-7163-3_3

Report Available

1 to 3 days

Method Name

Nephelometry