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Test Code A124 Alpha-1-Microglobulin, 24 Hour, Urine


Necessary Information


24-Hour volume (in milliliters) is required.



Specimen Required


Container/Tube: Plastic, 5-mL tube

Specimen Volume: 4 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. No preservative.

3. Mix well before taking 4-mL aliquot.

Additional Information: For multiple collections see Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens


Useful For

Assessment of renal tubular injury or dysfunction using 24-hour urine collections

 

Screening for tubular abnormalities

 

Detecting chronic asymptomatic renal tubular dysfunction(2)

Profile Information

Test ID Reporting Name Available Separately Always Performed
AIM Alpha-1-Microglobulin, 24 HR, U No Yes
A1MCR A1M/Creat Ratio No Yes
A1MC Alpha-1-Microglobulin Concentration No Yes
CRT24 Creatinine, 24 HR, U Yes, (Order CTU) Yes

Method Name

AIM, A1MCR: Calculation

A1MC: Immunonephelometry

CRT24: Enzymatic Colorimetric Assay

Reporting Name

Alpha-1-Microglobulin, 24 HR, U

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 7 days
  Ambient  7 days
  Frozen  7 days

Reference Values

≥18 years: <23 mg/24 hours

 

Reference values have not been established for patients who are less than 18 years of age.

Interpretation

Alpha-1-microglobulin above the reference values may be indicative of a proximal tubular dysfunction.

Clinical Reference

1. Akerstrom B, Logdberg L, Berggard T, Osmark P, Lindqvist A: Alpha(1)-microglobulin: a yellow-brown lipocalin. Biochim Biophys Acta. 2000 Oct 18;1482(1-2):172-184

2. Yu H, Yanagisawa Y, Forbes M, Cooper EH, Crockson RA, MacLennan RC: Alpha-1-microglobulin: an indicator protein for renal tubular function. J Clin Pathol. 1983 Mar;36(3):253-259

3. Hjorth L, Helin I, Grubb A: Age-related reference limits for urine levels of albumin, orosomucoid, immunoglobulin G, and protein HC in children. Scand J Clin Lab Invest. 2000 Feb;60(1):65-73

4. Pagana K, Pagana T, Papana T, eds: Mosby’s Diagnostic and Laboratory Test Reference. Mosby; 2020:632

Day(s) Performed

Varies

Report Available

1 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83883

LOINC Code Information

Test ID Test Order Name Order LOINC Value
A124 Alpha-1-Microglobulin, 24 HR, U 99075-4

 

Result ID Test Result Name Result LOINC Value
CR_A Creatinine, 24 HR, U 2162-6
AIM Alpha-1-Microglobulin, 24 HR, U 48414-7
A1MC Alpha-1-Microglobulin Concentration 99076-2
A1MCR A1M/Creat Ratio 99075-4
TM27 Collection Duration (h) 13362-9
VL69 Urine Volume (mL) 3167-4
CR_24 Creatinine Concentration, 24 HR, U 20624-3

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.